Abdul Hussein Moyet Al-Faisal; Wiaam Ahmad Al-Amili; Norrya A. Ali
Abstract
Fifty blood samples of leukemia patients were analyzed to detect the genetic alterations associated with disease. The results showed a high significant DNA damage leukemia group. A ...
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Fifty blood samples of leukemia patients were analyzed to detect the genetic alterations associated with disease. The results showed a high significant DNA damage leukemia group. A significant (P< 0.05) increase in MN is observed in Acute Lymphoblastic Leukemia (ALL) patients (0.012 ± 0.00056, 0.014± 0.00049 MN / cell respectively) and decreased Nuclear Division Index(NDI) level (1.615 ± 0.0052, 1.597± 0.0039 respectively ) when compared with control group (0.001 ± 0.00016 ; 1.845 ± 0.0091 respectively). DNA damage detected in Acute Lymphoblastic Leukemia (ALL) and Chronic Myeloid Leukemia (CML) patients with micronucleus (MN) is confirmed with statistically significantly higher COMET parameters (tail length =5.11±0.85, 5.66± 0.91; % DNA mean in tail= 0.072 ± 0.041%, 0.082±0.039 and tail moment=0.00044 ± 6.87, 0.00052±5.99 respectively). The results indicated that the leukemia patients were exposed to a high genotoxicity which damaged the lymphocytes DNA
