Author : Ali Kahdum, Bushra
Histopathological Effects of Burkholderia Mallei Isolated from Patients with Wound Infections on Mice
Engineering and Technology Journal,
2013, Volume 31, Issue 1, Pages 1-14
The histopathological effects 0f B. mallei on four organs (kidney, spleen, lung and liver) of mice injected with ( 104, 106, 108) CFU/ ml were studied. The results showed that the bacteria induced histopathological effects in all organs. In kidney the effects characterized by cytoplasmic vacculation and infiltration of inflammatory cells in addition to congestion and shrinkage of the glomeruli of the kidney,while effects in spleen characterized by enlargement of white pulp and necrosis in parenchymal tissue with formation of germinal center. Lung sections showed thickness in alveolar walls and infiltration of inflammatory cells with odema and congestion of blood vessels. Liver sections showed cytoplasmic vacculation and infiltration of inflammatory cells.