The aim of this study was to investigate the ability of methanolic extract of soybean to eliminat the harmfull effects of mitomycin C. By using sperm abnormalities test of male mice (Mus musculus).Seventyfive mice were used and divided into five groups by 15 mice for each group and each group was divided in turn into five groups: group 1 used as negative control , group 2 as positive control, were treated with mitomycin C (MMC) at 2mg/kg b.wt. intraperitonealy (i.p.) , while tested the remaining three groups with alcohol extract in concentrations ranged (2, 4, 8) mgheadday within periods (1, 3, 5) week. The results don’t show presence of abnormal change in the form of the heads of sperm in the stages of spermatids ,spermatocytes and spermatogonia in sperm cells and. So we cann’t conclude that doses of soybean extract may permanently sterilize mice, and so cann’t ability to recovering the effects of MMC.