The current study has been applied on the sector of the Tigris River runs from the Dejail area in Salaheldin province even the outskirts of the city of Baghdad near Muthanna Bridge, for the purpose of the follow-up changes of the physico-chemical factors of river water as a result of human activities affecting in the river environment and of throwing household waste, wastewater, fish cages, agricultural and industrial wastes, six different stations were selected along the course for a distance of about 50 km, and chosen on the basis of the diversity of human activities and given symbols (ST1, ST2, ST3, ST4, ST5and ST6), respectively. Water samples have been collected per month for a full year from January up to December (2014). Many factors such as temperature of air and water, water flow velocity, depth, light transmittance, turbidity, (EC, TDS, pH, DO, BOD5, Ca, Mg , TH, TA, NO2 , NO3, PO4, SiO3, SO4,) in addition to Cl were measured. The results showed that the ranges of air and water temperature were between (12.16-40.13 and 10.5-30.27) °C respectively, and flow velocity ranged from (0.29 to 4.17) m/sec; depth (3.75 -7.5) meters, light transmittance (10.0-133) cm, turbidity (10-300) NUT, EC, (673-2028) ms/cm, salinity (0.41-1.2) part per thousand, TDS (574-1017) mg/l, pH (6.70-7.9), DO (2.1-11.7) mg/l, BOD5 (0.18-5.66) mg/l , Ca (132-520) mg/l, Mg (19 -47) mg/l, TH value varied from (231 to 640) and TA (69-158) mg CaCO3/l, NO2 (0.001-0.008), NO3 (0.30-1.4) mg/l, PO4 (0.004-5.12) mg/l, SiO3 (1.95-5.5) mg/l, SO4 (62-702) mg/l and Cl, (26-110) mg/l. From the results, it can be concluded that the volatility in most of the studied factors between the sites and the values of months significantly subjected to the effects of human activities and diversity, and most of these values have exceeded the conditions by Iraqi and international determinants of the river water.