Synthesis natural hydroxyapatite in different nanostructure shapes and sizes such that the toxicity is reduced to the minimum for an individual application. However, the synthesis and functionalization processes are accomplished using chemical method. The morphology of the HAP nanoparticles changes from rod to spherical. Rod shaped particle are found with length between 10-20 nm while the spherical particles are found with radius less than 10 nm. But for the pure HAP only rod morphology observed with the size ranging from 30-60 nm.