Multiple myeloma is a cancer that forms in a type of white blood cell called a plasma cell. Plasma cells help you fight infections by making antibodies that recognize and attack germs. This study aimed to investigate effect of aqueous extract and silver nanoparticles from Punica granatum peel on the ability of phagocytic cells in patients with Multiple myeloma. Chemical components of Punica granatum were investigated. It was found that they contained most of chemical compounds such as Glycosides, Flavonoids, Alkaloids, Saponins, Tanins, Resins, Terpenes, and Steroids. Our results showed the presence of a significant decrease (p˂0.001) in ability of phagocytic cells in patients, when the results were compared to the control group which included healthy individuals. While, the results showed increase in the percentage of phagocytic cells after added Punica granatum peel silver nanoparticles by increases activity of NADPH enzyme. This increase indicates that the Punica granatum peel silver nanoparticles contain chemical components which act as immune modulators by increase of the percentage of phagocytic cells to engulf bacteria.