Synthetic biomaterials for bone repair and substitute must be yield to critical criteria , one of them, their mechanical properties should not be very less than that for natural bone to prevent fast failure, nor much higher to prevent stress shielding effect which led to fast implant collapse. Other important issue, it should not cause inflammation in implantation region. According to these criteria, many researchers investigated several biomaterials. Titanium dioxide (TiO2) reinforced polyetheretherketone (PEEK) biocomposite is considered a promising biomaterials, because of their superior properties and good biocompatibility with host tissue. Alumina (Al2O3), considered a bio inert ceramic used in this work to modify mechanical properties. Hot pressing technique adopted in this work with pressing pressure of 50 MPa at 370,380,390, and400 C° compounding temperatures to produce different compositions implants. Animal model used to study inflammation behaviour for implants as a comparison with control group. X-Ray radiological test were carried out for both, implants and control regions. Mechanical testing shows good values, similar to natural bone. No inflammation observed in injury area.