This study involved studying fatigue crack propagation in elastic-plastic and linear elastic fracture mechanics LEFM fracture mechanics EPFM for each bovine and cadaveric human cortical bone. The results of the fatigue crack propagation showed that the fatigue crack propagation in elastic-plastic fracture mechanics is better than fatigue crack propagation in linear elastic fracture mechanics for comparison of the bone at small frequencies. Therefore, fatigue crack growth rate in cadaveric human bone is larger than bovine cortical bone. In addition, the cutting of the bone by hand saw is the better method than any an electric cutting machine.