In general, internal vibrations within the pipelines caused by fluids being passing through a pipeline system can cause. These pipeline system can damage by the sudden amplified vibrations that weren’t considered at the design of the system, and flow induced vibrations resonate with the pipes natural frequency. Therefore, it is important to predict and identify the pipeline system vibrations during its lifetime. In this study by using MATLAB code as a CFD solver, it studied the forced and free vibrations caused by fluid flows at Reynolds number ranged as 0 < Re < 2500 for laminar flow and ranged as 104 < Re < 105 for turbulent flow. The working fluid has chosen as of (Al2O3, TiO2, SiO2 and water) with different nanoparticle volume fraction of (0 to 2% vol.). These fluids flow in simply supported pipe with different lengths and diameters. The results presented the effect of pipe and fluid parameter upon the fluid critical velocity and fundamental natural frequencies. The results showed that the pipe natural frequency increased with increasing with decreasing the pipe length and diameter. In addition, it showed that the pipe natural frequency decreased when using the different nanoparticle depressed in the water and with increasing the volume fraction.