As maxillofacial defects increased due to cancer; it became necessary to select high-quality prosthetic materials in this field. Silicone rubber is widely used in damaged maxillofacial affected areas replacement surgery as bio material. The aim of this research, prepared a nano composites materials, from polymer blend (silicone rubber: 5% PMMA) reinforced by different types of nano-powders; pomegranate Peels Powder (PPP), Seeds powder of dates Ajwa (SPDA) and TiO2 nano-powders with loading level (0.0, 0.1, 0.2, 0.3 and 0.4%). Some physical properties such as density, water absorption, and Thermo-Physical test, FTIR analysis, as well as, FTIR, antibacterial tests were done on prepared samples. The results showed that the composites material based of polymer blend with optimum percent are of 0.2% of pomegranate Peels Powder (PPP), 0.3% of Seeds powder of dates Ajwa (SPDA) and 0.1% of TiO2 nano-powders that have ideal characteristic. Also for antibacterial tests, polymeric blend composites with optimum percent of this nano-powders show that more antibacterial efficiency against S.aureus bacteria than E.coli bacteria.