This study aimed to investigate the effects of ethanolic crude extract of Petroselium cripum leaves on the proliferation of the cancer cell lines AMN-3. The cytotoxicity of cancer cell line of concentrations of (0.95, 1.9,3.8,7.7,15.5,31.25,62.5,125,250,500,1000,2000, 4000, 6000, 8000, 10000, 12000, 14000 and 16000) μg/ml showed there was no inhibition observable in concentration (o.95, 1.9, 3.8, 7.7, 15.5, 31.25, 62.5 and125) μg/ml. While at concentration of 250,500 and 1000 mg/ml the inhibition percentage was less than 50%.But at concentration of 2000 and 4000μg/ml the inhibition percentage was(63%,66%) respectively , while after 48hrs the concentration of
(6000,8000,10000,12000,14000 and16000)μg/ml the inhibition percentage was more than70% .This study was found that the alcoholic extract has toxic effect on cancer cell line . AMN-3 cell line the inhibition percentage was71.97% and78.20% at concentration of 6000μg/ml and 16000μg/ml after 24hrs; while after 48hrs the percentage was 74.04% and 80.96% respectively,but after 72hrs the percentage was 75.08% and82.69% respectively.From this result we can concluded that this plant have a promosing medicinal plant for effect on cancer,through out the toxic
effects on cancer cell line.