Quantitative Determination of Paracetamol in Pharmaceutical Formulations by FTIR Spectroscopy
Engineering and Technology Journal,
2010, Volume 28, Issue 15, Pages 5028-5035
AbstractThe aim of this work was to use a spectrophotometric method for the
determination of paracetamol in pharmaceutical formulations.The quantification of paracetamol through infrared spectroscopy was developed and validated for pharmaceuticals in tablet forms. The method involves the extraction of the active ingredient with chloroform and the measurement of the area of the infrared band corresponding to the carbonyl group centered at 1650cm-1. The specificity,
linearity,detection limits,precision and accuracy of the calibration curve, paracetamol extraction, infrared analysis and data manipulation were determined in order to validate the method. The statistical results were compared with the quantification of paracetamol through UVdetection.The recovery values obtained in the analysis of pharmaceuticals are within the range 98-105%.
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