The oral administration of the aqueous extract of Teucrium polium to a
mature male mice in daily oral doses of 50 mg/kg body weight (group II) and 100
mg/kg body weight (group III) for eight consecutive weeks were resulted in
significant increase (P<0.05) in the testicular weight in the treated groups in
comparison with control. The aqueous extract affected the spermatogenesis which
demonstrated by an increase in leydig cell, spermatogonia, spermatocytes and
spermatozoa. The hormonal profile was influenced by the aqueous extract. The
testosterone level was significantly increased (P<0.05) in the treated groups, but
no significant differences (P>0.05) in urea and uric acid levels between control
and the treated groups were shown. The kidneys of the group III were affected and
showed degenerative changes and necrosis in nucleolus of cell of tubules and there
is destruction in glumerular by increscent of mesenchymal cells.