In this study the antibacterial activity of the methanolic extract of Myrtus communis was investigated against Escherichia coli, Klebsiella pneumonia, Pseudomonas aerogenosa and Staphylococcus aureus by agar disc diffusion. Serial concentrations of the extract were tested (1, 2, 3, 4 and 5mg/ml). Most of the extract concentrations showed a relatively high antibacterial activity against all the tested bacteria. The concentration 5mg/ml of plant extracted has the maximum antibacterial activity against all bacterial isolates. Antimicrobial activity of Myrtus communis extract was compared with a number of antibiotics like: Ampicilin (AM10), Tetracyline (TE30), Erythromycin (E15), Carbnicilin (PY100) and Gentamycin (CN10) using antibiogram test. Antibacterial activity of latest concentration (5mg/ml) of Myrtus communis was better than that to Gentamicin against Klebsiella pneumoniae, Escherichia coli and Pseudomonas aerogenosa.