The present study was carried out to determine the effect of methanol extract of Anethumgraveolens(Dill) on serum lipoproteins in hypercholesterolaemic mice.A total of 24 male mice (average 25gm body weight) were used in this study. Mice were divided into four groups was injected with 100mg/kg ofalloxan to induce hyperglycemic in mice, the first group (1) was used as control (+ve) group (6 mice) which fed on basal diet only and the other three groups fed on basal diet containing 0.5, 1 and 2mg/ml of methanol extract (single daily dose of 1 ml). The experimental feeding period was 21 days.The changes in serum triglyceride (TG), total cholesterol (TC), high density lipoprotein-cholesterol (HDL-C) and low density lipoprotein-cholesterol (LDL-C) were measured by using enzymatic kits.However, the HDL-Cconcentrate decreased relative to control mice. Treatment of hyperlipidaemic mice with dill extract in concentration 1 and 2mg/ml up to 21 days reversed the serum lipid levels compared to mice which were fed basal diet only.