A study investigated the effects of paracetamol on the level of liver enzyme activities that induced hepatotoxicity in white albino male mice. In this study forty mice where used, divided to four group, three of them where ingested orally different doses of paracetamol for three month and compared with control group, also GOT, GPT, ALP and GGT where measured.
Biochemical analysis showed highly significant difference in serum GOT, GPT, ALP and GGT in all experimental groups as compared to control group. In conclusion the paracetamol induced hepatotoxicities in mice in prolong period treatment.