Synthesis of Some New Derivatives of Pyrrolidine-2-one and Studying Their Antibacterial Potentials

Authors

• Nadia Betti, Materials Engineering Department, University of Technology, Baghdad, IraqFollow
• Redha Hussain, Department of Chemistry, Mustansiriyah University, Baghdad, Iraq.
• Sahar Kadhem, Department of Chemistry, Mustansiriyah University, Baghdad, Iraq.

Keywords

Pyrrolidine-2-one, Lactamization, biological activity

Document Type

Research Paper

Abstract

New derivatives of pyrrolidine-2-one have been synthesized through lactamization of γ –butyrolactone (GBL) by hydrazine hydrate (80%), ethylene diamine and ethanol amine to afford compounds (1-aminopyrrolidin-2-one), (1-(2-aminoethyl)pyrrolidine-2-one) and (1-(2-hydroxyethyl)pyrrolidine-2-one), respectively. Compound (1-aminopyrrolidin-2-one) underwent several reactions to synthesize the rest of these derivatives. All synthesized compounds were approved by their FT-IR, 1H-NMR and some by Mass spectra. The biological activities of these derivatives were evaluated against Escherichia coli and Staphylococcus aureus. Many of these derivatives showed moderate biological activity against one or both kind of bacteria in comparison to amoxicillin and some showed no biological activity at all.

Recommended Citation

Betti, Nadia; Hussain, Redha; and Kadhem, Sahar (2026) "Synthesis of Some New Derivatives of Pyrrolidine-2-one and Studying Their Antibacterial Potentials," Engineering and Technology Journal: Vol. 38: Iss. 3, Article 25.
DOI: https://doi.org/10.30684/etj.v38i3B.706

DOI

10.30684/etj.v38i3B.706

First Page

128

Last Page

141